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Reginald F Frye Selected Research

Mephenytoin (Mesantoin)

9/2006Liver disease selectively modulates cytochrome P450--mediated metabolism.
3/2005Cytochrome P-450 activity is differentially altered in severely injured patients.
10/2002Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.

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Reginald F Frye Research Topics

Disease

5Hypertension (High Blood Pressure)
01/2022 - 11/2011
5Kidney Diseases (Kidney Disease)
02/2014 - 11/2003
3Critical Illness (Critically Ill)
01/2018 - 06/2003
3Non-alcoholic Fatty Liver Disease
01/2018 - 10/2014
3Drug-Related Side Effects and Adverse Reactions
10/2009 - 08/2002
2Insulin Resistance
01/2018 - 04/2014
2Wounds and Injuries (Trauma)
01/2018 - 03/2005
2Dyslipidemias (Dyslipidemia)
10/2016 - 08/2008
2Hyperglycemia
10/2016 - 01/2016
2Chronic Kidney Failure (Chronic Renal Failure)
02/2014 - 10/2009
2Glomerulonephritis
02/2014 - 09/2012
2Type 2 Diabetes Mellitus (MODY)
01/2013 - 04/2004
2Melanoma (Melanoma, Malignant)
11/2011 - 08/2002
2Peritonitis
01/2007 - 12/2004
2Multiple Organ Failure (MODS)
03/2005 - 06/2003
1Delirium
01/2020
1Alcoholic Fatty Liver
01/2018
1Venous Thromboembolism
01/2018
1Fibrosis (Cirrhosis)
01/2018
1Metabolic Syndrome (Dysmetabolic Syndrome X)
06/2015
1Diabetes Mellitus
04/2014
1Infections
02/2014
1Chronic Renal Insufficiency
02/2014
1Anemia
02/2014
1Edema (Dropsy)
01/2013
1Chronic Disease (Chronic Diseases)
01/2013
1Postoperative Pain
12/2012
1Pain (Aches)
12/2012
1Headache (Headaches)
12/2012
1Lupus Nephritis
09/2012
1Vasculitis (Vasculitides)
09/2012
1Uremia
10/2009
1Infarction (Infarctions)
08/2009
1Hemorrhage
08/2009
1Brain Ischemia (Cerebral Ischemia)
08/2009
1Ischemic Stroke
08/2009
1Stroke (Strokes)
08/2009
1Neoplasms (Cancer)
12/2008
1Acute-Phase Reaction
12/2008

Drug/Important Bio-Agent (IBA)

8Pharmaceutical PreparationsIBA
02/2014 - 10/2002
7EnzymesIBA
02/2014 - 08/2002
5Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
11/2011 - 06/2003
4Pioglitazone (Actos)FDA Link
01/2018 - 01/2013
4ChlorzoxazoneFDA LinkGeneric
09/2006 - 10/2002
3Biomarkers (Surrogate Marker)IBA
01/2020 - 08/2009
3Atenolol (Tenormin)FDA LinkGeneric
10/2016 - 01/2013
3Cytochrome P-450 CYP3AIBA
02/2014 - 10/2009
3Caffeine (No Doz)FDA LinkGeneric
12/2012 - 10/2002
3Protein Isoforms (Isoforms)IBA
12/2008 - 11/2003
3CytochromesIBA
09/2006 - 10/2002
3Mephenytoin (Mesantoin)FDA Link
09/2006 - 10/2002
2Tryptophan (L-Tryptophan)FDA Link
01/2020 - 01/2018
2KynurenineIBA
01/2020 - 01/2018
2Antihypertensive Agents (Antihypertensives)IBA
01/2016 - 01/2013
2Amino AcidsFDA Link
06/2015 - 04/2014
2Glucose (Dextrose)FDA LinkGeneric
06/2015 - 04/2014
2Tyrosine (L-Tyrosine)FDA Link
04/2014 - 10/2004
2fexofenadine (Allegra)FDA LinkGeneric
02/2014 - 10/2009
2Hypoglycemic Agents (Hypoglycemics)IBA
01/2013 - 04/2004
2Cytochrome P-450 CYP2B6 (CYP2B6)IBA
09/2012 - 06/2010
2Dextromethorphan (Racemethorphan)FDA LinkGeneric
11/2011 - 10/2002
2Midazolam (Versed)FDA LinkGeneric
11/2011 - 10/2009
2Cytochrome P-450 CYP2D6 (CYP2D6)IBA
11/2011 - 03/2003
2Atorvastatin (Lipitor)FDA Link
08/2009 - 08/2008
2Interleukin-6 (Interleukin 6)IBA
06/2003 - 10/2002
1Metoprolol (Toprol-XL)FDA LinkGeneric
01/2022
1TabletsIBA
01/2022
1Kynurenic Acid (Kynurenate)IBA
01/2020
1nasIBA
01/2018
1Alanine (L-Alanine)FDA Link
01/2016
1Aromatic Amino Acids (Aromatic Amino Acid)IBA
06/2015
1AcidsIBA
04/2014
1Isoleucine (L-Isoleucine)FDA Link
04/2014
1Valine (L-Valine)FDA Link
04/2014
1Leucine (L-Leucine)FDA Link
04/2014
1Phenylalanine (L-Phenylalanine)FDA Link
04/2014
1telaprevirIBA
02/2014
1Flurbiprofen (Froben)FDA LinkGeneric
02/2014
1Cytochrome P-450 CYP2C9IBA
02/2014
1N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamideIBA
02/2014
1cytidylyl-(3'-5')-cytidine (CpC)IBA
12/2012
1Analgesics (Analgesic Drugs)IBA
12/2012
14-hydroxycyclophosphamideIBA
09/2012
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
09/2012
1Sorafenib (BAY 43-9006)FDA Link
11/2011
1IsoenzymesIBA
11/2011
1Omeprazole (Prilosec)FDA LinkGeneric
11/2011
1Lipase (Acid Lipase)FDA Link
11/2011
1Cytochrome P-450 CYP2C19IBA
11/2011
1Bupropion (Wellbutrin)FDA LinkGeneric
06/2010
1hydroxybupropionIBA
06/2010
1Proteins (Proteins, Gene)FDA Link
10/2009
11-hydroxymethylmidazolamIBA
10/2009
1Protective AgentsIBA
08/2009
1Hemoglobins (Hemoglobin)IBA
08/2009

Therapy/Procedure

5Therapeutics
02/2014 - 08/2002
1Precision Medicine
02/2014
1Oral Surgery (Maxillofacial Surgery)
12/2012
1Analgesia
12/2012
1Oral Administration
10/2009